The Medipix technology developed by the Medipix2 and Medipix3 collaborations represents a new tool within the portfolio of non-destructive inspection methods used by art conservators, restorers, galleries, auction houses and other experts in the field of art studies. The modern cutting-edge X-ray imaging detectors enable X-ray spectral imaging (XRSI), material resolved X-ray imaging and soon X-ray “colour” imaging (XRCI) useful for the inspection of paintings. The high-resolution spectral information acquired by these devices helps assess the condition of paintings and identify painted-over or forged pieces. The technology has been commercialised by InsightART, a start-up company based in Prague.