As the world started collaborating to find solutions against COVID-19, it became apparent that large-scale, collaborative analysis of medical, demographic, social, and financial data was critical to address challenges at an international scale. CERN made available its knowledge in data analysis, as well as tools like Zenodo and REANA to support institutes and universities in areas such as excess mortality analysis, gender-specific impacts, relations of COVID-19 with environmental pollution, or transport networks. The initial collaboration between CERN openlab and the One Health Initiative of the University of Florida, involves now several international initiatives.